Hold on Tight: Cadherins
A two page magazine article featuring cadherin proteins.
Structures were accessed from the Protein Data Bank then modeled in UCSF Chimera and Cinema 4D using the ePMV plugin. Models were rendered in Cinema 4D and finally edited using Adobe Photoshop and Adobe Illustrator.
Client: Derek Ng
Audience: Interested public
Format: Print (magazine), 11 x 17"
Media: UCSF Chimera, Cinema 4D, Adobe Photoshop, Adobe Illustrator
Date: July 2018
PDB IDs: 3Q2V, 4ZT1, 3L6X, 1I7W, 4IGG, 4K1O, 1J6Z, 3LUE.
Beavon IR. The E-cadherin–catenin complex in tumour metastasis: structure, function and regulation. Eur J Cancer. 2000;36(13):1607–20.
Harrison OJ, Jin X, Hong S, Bahna F, Brasch J, Wu Y, et al. The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. 2011;19(2):244–56.
Parisini E, Higgins JMG, Liu J huan, Brenner MB, Wang J huai. The Crystal Structure of Human E-cadherin Domains 1 and 2, and Comparison with other Cadherins in the Context of Adhesion Mechanism. J Mol Biol. 2007;373(2):401–11.
Huber AH, Weis WI. The Structure of the B-Catenin/E-Cadherin Complex and the Molecular Basis of Diverse Ligand Recognition by B-Catenin. Cell. 2001;105:391–402.
Sotomayor M, Schulten K. The allosteric role of the Ca2+ switch in adhesion and elasticity of C-cadherin. Biophys J. 2008;94(12):4621–33.